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Research Areas


X-ray Technology

Exploring the power of 4th generation synchrotron and free electron sources in providing high brightness x-rays for new applications.
Current programs include the development of high resolution and/or high speed x-ray imaging, coherent diffraction imaging of nanostructured materials.

  1. Chi-Feng Huang et al.  “XFEL coherent diffraction imaging for weakly scattering particles using heterodyne interference.” AIP Advances 10 (5), 055219 (2020). DOI: 10.1063/1.5129406

  2. Tsung-Yu Chen et al. "Full-field microimaging with 8 keV X-rays achieves a spatial resolutions better than 20 nm" Optics Express 19, 19919-19924 (2011). DOI: 10.1364/OE.19.019919

  3. Chien, CC. et al. "Gold nanoparticles as high-resolution X-ray imaging contrast agents for the analysis of tumor-related micro-vasculature". J Nanobiotechnol 10, 10 (2012). DOI: 10.1186/1477-3155-10-10

  4. Y. Hwu et al. “Using photoelectron emission microscope with hard-x-rays”, Surface Science 480, 188 (2001). DOI: 10.1016/S0039-6028(01)00834-2


Develop state-of-the-art nanofabrication techniques aiming to fabricate x-ray optical devices, such as Fresnel zone plates, for nanoscale x-ray imaging.

  1. Yu-Tung Chen et al. “Full-field Hard X-Ray Microscopy below 30 Nanometers: a Challenging Nanofabrication Achievement”, Nanotechnology, 19, 395302 (2008); reported by NanoWerk.

  2. Syue-Ren Wu et al. “Hard-X-ray Zone Plates: Recent Progress” Materials 5, 1752-1773 (2012). DOI: 10.3390/ma5101752.  

  3. Seung Kwon Seol et al. “Three-Dimensional (3D) Polypyrrole Microstructures with High Aspect Ratios Fabricated by Localized Electropolymerization”, Macromolecules 41, 3071-4 (2008). DOI: 10.1021/ma702786g



Taking advantage of the unique x-ray synthesis approach NanoX Lab invented, our nanosynthesis program focuses on synthesizing well dispersed nanoparticles with superior performance and characteristics for x-ray imaging application and biomedical research.

  1. M-T Li et al. “Gold nano-mesh synthesis by continuous-flow X-ray irradiation”, J. Synchrotron Rad. 26, 1929-1935 (2019). DOI: 10.1107/S1600577519011834

  2. Chang-Hai Wang et al. “Aqueous gold nanosols stabilized by electrostatic protection generated by X-ray irradiation assisted radical reduction”, Materials Chemistry & Physics 106, 323-329 (2007). DOI: 10.1016/j.matchemphys.2007.06.024

  3. S-Ja Tseng et al. “Controlled hydrogel photopolymerization inside live systems by X-ray irradiation”, Soft Matters 8, 1420-1427 (2012). DOI: 10.1039/C1SM06682J

  4. Sheng-Feng Lai et al. “Size control of gold nanoparticles by intense X-ray irradiation: the relevant parameters and imaging applications”, RSC Advances, 2, 6185–6191 (2012). DOI: 10.1039/C2RA20260C


Using the unique technologies NanoX Lab developed, the nanodevices, and the nanoparticles, we pushed x-ray imaging to a new level and created new biomedical applications.

  1. An-Lun Chin et al. “A Synchrotron X-ray Imaging Strategy to Map Large Animal Brains”, Chinese J. Phys. 65, 24-32 (2020). DOI: 10.1016/j.cjph.2020.01.010

  2. Chi-Feng Huang et al. “Free-Electron-Laser Coherent Diffraction Images Individual Drug-Carrying Liposome Particles in Solution”, Nanoscale 10, 2820-2824 (2018). DOI: 10.1039/C7NR09395K

  3. Yeukuang Hwu et al. “Q&A: Why use synchrotron x-ray tomography for multi-scale connectome mapping?”, BMC Biology 15, 122 (2017). DOI: 10.1186/s12915-017-0461-8

  4. H. R. Wu et al. “Nanoresolution Radiology of Neurons”, J. Phys. D 45, 242001 (2012). DOI: 10.1088/0022-3727/45/24/242001

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